P11-4 vs Pleurocidin
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and Pleurocidin (Pleurocidin (winter flounder antimicrobial peptide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | P11-4 | Pleurocidin |
|---|---|---|
| Category | Dental & Oral | Marine-Derived |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Pleurocidin (winter flounder antimicrobial peptide) |
| Molecular Weight | 1466 Da | ~2.8 kDa |
| Half-Life | local activity for hours; peptide degraded over time | NR |
| Amino Acids | 11 | 25 |
| Typical Dose | 0.5-5 mg per lesion | NR |
| Route | Topical/Intraoral | in vitro|topical preclinical |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 82 |
| Research Status | Clinical | Pre-clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Pleurocidin Benefits
- ✓antimicrobial
- ✓anticancer lead
- ✓endotoxin neutralization
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Pleurocidin Dosing
NR|NR
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Pleurocidin Side Effects
- ⚠membrane toxicity
- ⚠hemolysis at high concentrations
- ⚠protease sensitivity
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Pleurocidin
Preclinical studies report membrane-active killing of bacteria and some activity against cancer cell lines. Multiple analogs have been developed to reduce toxicity while preserving potency.
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