TAT
HIV-1 TAT protein transduction domain
YGRKKRRQRRR Amino Acids · MW: 1560.9
Amino Acids
YGRKKRRQRRR
Molecular Weight
1560.9
Half-life
minutes to <1 h in serum; formulation-dependent
Research Score
4.6
Studies
92
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is TAT?
A classic cationic cell-penetrating peptide derived from the HIV-1 transactivator of transcription protein. It is widely used to ferry proteins, peptides, and nucleic acids into cells in preclinical drug-delivery studies.
Key Benefits & Mechanisms
high membrane translocation
broad cargo compatibility
well-characterized uptake biology
Research Summary
Extensively used as a modular CPP for intracellular delivery of proteins, siRNA, and nanoparticles; activity is often improved by cargo conjugation strategies and endosomal escape motifs.
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