Penetratin
Antennapedia-derived penetratin
RQIKIWFQNRRMKWKK Amino Acids · MW: 2243.7
Amino Acids
RQIKIWFQNRRMKWKK
Molecular Weight
2243.7
Half-life
minutes to ~1 h; improved by stabilization
Research Score
4.5
Studies
90
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Penetratin?
Penetratin is a 16-residue CPP derived from the Drosophila Antennapedia homeodomain. It is a foundational delivery peptide for intracellular transport of biomolecules and imaging agents.
Key Benefits & Mechanisms
efficient cellular uptake
small, compact carrier
widely validated in vitro and in vivo
Research Summary
Used to enhance delivery of oligonucleotides, peptides, and small-molecule conjugates, with uptake commonly dependent on charge density and membrane interactions.
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