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LongevityPhase III Trials

SS-31

Elamipretide (Mitochondria-Targeted Peptide)

4 Amino Acids · MW: 640.76 Da

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Amino Acids

4

Molecular Weight

640.76 Da

Half-life

~4 hours

Research Score

4.5

Studies

156

Storage

N/A

What is SS-31?

SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that concentrates in the inner mitochondrial membrane. It stabilizes cardiolipin, improves electron transport chain efficiency, and reduces reactive oxygen species. Being developed for mitochondrial myopathies and heart failure.

Key Benefits & Mechanisms

Targets and repairs mitochondria

Reduces oxidative stress at source

Improves cellular energy production

Cardioprotective in heart failure

Reverses age-related mitochondrial decline

Improves exercise capacity

Stabilizes cardiolipin

Research Summary

SS-31 has advanced clinical evidence with multiple Phase II and III trials. Breakthrough therapy designation for Barth syndrome. Phase III trials for primary mitochondrial myopathy and heart failure. One of the most clinically advanced mitochondrial-targeted therapeutics.

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