SS-31
Elamipretide (Mitochondria-Targeted Peptide)
4 Amino Acids · MW: 640.76 Da
Amino Acids
4
Molecular Weight
640.76 Da
Half-life
~4 hours
Research Score
4.5
Studies
156
Storage
N/A
What is SS-31?
SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that concentrates in the inner mitochondrial membrane. It stabilizes cardiolipin, improves electron transport chain efficiency, and reduces reactive oxygen species. Being developed for mitochondrial myopathies and heart failure.
Key Benefits & Mechanisms
Targets and repairs mitochondria
Reduces oxidative stress at source
Improves cellular energy production
Cardioprotective in heart failure
Reverses age-related mitochondrial decline
Improves exercise capacity
Stabilizes cardiolipin
Research Summary
SS-31 has advanced clinical evidence with multiple Phase II and III trials. Breakthrough therapy designation for Barth syndrome. Phase III trials for primary mitochondrial myopathy and heart failure. One of the most clinically advanced mitochondrial-targeted therapeutics.
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