Somatostatin

Somatostatin-14

14 Amino Acids · MW: 1637.85

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Amino Acids

Molecular Weight

1637.85

Half-life

1-3 min

Research Score

4.2

Studies

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Somatostatin?

Endogenous tetradecapeptide that inhibits nociceptive neurotransmission and inflammatory signaling. It has been explored as a non-opioid candidate for visceral, inflammatory, and neuropathic pain.

Key Benefits & Mechanisms

nociceptive inhibition

anti-inflammatory signaling

visceral pain modulation

Research Summary

Somatostatin reduces release of multiple excitatory mediators and can suppress pain signaling in preclinical and limited translational work. Its analgesic use is not standard, but the peptide is real and mechanistically relevant to pain control.

Related Peptides

Met-enkephalin

Tyr-Gly-Gly-Phe-Met

Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.

Pain Management

Leu-enkephalin

Tyr-Gly-Gly-Phe-Leu

Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.

Pain Management

DADLE

[D-Ala2, D-Leu5]-enkephalin

DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.

Pain Management

DPDPE

[D-Pen2, D-Pen5]-enkephalin

DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.

Pain Management