Semax
Synthetic ACTH Analog (Met-Glu-His-Phe-Pro-Gly-Pro)
7 Amino Acids · MW: 813.93 Da
Amino Acids
7
Molecular Weight
813.93 Da
Half-life
~2-3 minutes (intranasal)
Research Score
4.6
Studies
142
Storage
N/A
What is Semax?
Semax is a synthetic heptapeptide analog of ACTH(4-7) developed at the Institute of Molecular Genetics in Russia. It enhances cognitive function, memory, and neuroprotection through BDNF upregulation and modulation of serotonergic and dopaminergic systems. Approved in Russia as a nootropic and neuroprotective agent.
Key Benefits & Mechanisms
Cognitive enhancement and memory improvement
BDNF and NGF upregulation
Neuroprotective in ischemic conditions
Attention and focus improvement
Anxiolytic properties without sedation
Immune system modulation
Potential antidepressant effects
Research Summary
Semax is approved in Russia for clinical use as a nootropic and neuroprotective agent. Multiple human studies demonstrate cognitive enhancement, neuroprotection in stroke patients, and BDNF upregulation. One of the most well-studied nootropic peptides.
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