NootropicApproved (Russia)

Semax

Synthetic ACTH Analog (Met-Glu-His-Phe-Pro-Gly-Pro)

7 Amino Acids · MW: 813.93 Da

Amino Acids

7

Molecular Weight

813.93 Da

Half-life

~2-3 minutes (intranasal)

Research Score

4.6

Studies

142

Storage

N/A

What is Semax?

Semax is a synthetic heptapeptide analog of ACTH(4-7) developed at the Institute of Molecular Genetics in Russia. It enhances cognitive function, memory, and neuroprotection through BDNF upregulation and modulation of serotonergic and dopaminergic systems. Approved in Russia as a nootropic and neuroprotective agent.

Key Benefits & Mechanisms

Cognitive enhancement and memory improvement

BDNF and NGF upregulation

Neuroprotective in ischemic conditions

Attention and focus improvement

Anxiolytic properties without sedation

Immune system modulation

Potential antidepressant effects

Research Summary

Semax is approved in Russia for clinical use as a nootropic and neuroprotective agent. Multiple human studies demonstrate cognitive enhancement, neuroprotection in stroke patients, and BDNF upregulation. One of the most well-studied nootropic peptides.