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NootropicPre-clinical

Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

6 Amino Acids · MW: 507.63 Da

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Amino Acids

6

Molecular Weight

507.63 Da

Half-life

~4-6 hours

Research Score

4.1

Studies

34

Storage

N/A

What is Dihexa?

Dihexa is a potent nootropic peptide derived from angiotensin IV. It is reported to be approximately 10 million times more potent than BDNF at promoting synaptic connectivity. It enhances cognitive function by driving new synapse formation through hepatocyte growth factor (HGF) pathway activation.

Key Benefits & Mechanisms

Extremely potent cognitive enhancer

Promotes synaptogenesis (new synapse formation)

Activates HGF/c-Met pathway

Crosses the blood-brain barrier orally

Potential for neurodegenerative conditions

Enhanced memory consolidation

Improved spatial learning

Research Summary

Dihexa has remarkable pre-clinical data showing extraordinary cognitive enhancement in animal models. Its potency is unprecedented among nootropics. However, human clinical data is very limited. The HGF pathway involvement raises theoretical safety concerns that need further study.

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