PH
L-prolyl-L-hydroxyproline
Pro-Hyp Amino Acids · MW: 228.25
Amino Acids
Pro-Hyp
Molecular Weight
228.25
Half-life
transient; hours
Research Score
4.8
Studies
90
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is PH?
A major bioavailable dipeptide from collagen hydrolysate and gelatin digestion. It has been repeatedly detected in blood after oral collagen intake.
Key Benefits & Mechanisms
skin hydration support
connective tissue support
collagen turnover marker
Research Summary
Pro-Hyp is one of the best-characterized collagen-derived peptides in humans after oral ingestion. In vitro studies report effects on fibroblasts, extracellular matrix markers, and hyaluronic-acid related signaling, but clinical data are largely based on mixed collagen peptide products.
Related Peptides
Pro-Gly-Pro
L-Prolyl-glycyl-L-proline
A collagen-breakdown tripeptide generated during matrix proteolysis, especially from collagen-rich tissues. It is best known as a neutrophil chemoattractant and a biomarker of collagen turnover.
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Asp-Gly-Glu-Ala
A type I collagen-derived tetrapeptide used in cell-adhesion and bone-biology research. It interacts with collagen-related signaling pathways and is commonly studied in scaffolds and wound-healing models.
Collagen PeptidesGFOGER
Gly-Phe-Hyp-Gly-Glu-Arg
A high-affinity type I collagen integrin-binding motif containing hydroxyproline. It is heavily used in biomaterials to promote cell attachment, osteoblast behavior, and matrix organization.
Collagen PeptidesGPH
Glycyl-L-prolyl-L-hydroxyproline
A collagen-derived tripeptide commonly detected after oral collagen hydrolysate intake. It is studied as a circulating marker peptide and for possible extracellular-matrix signaling.
Collagen Peptides