p277
Heat shock protein 60-derived peptide p277 (DiaPep277)
24 Amino Acids · MW: ≈2.6 kDa
Amino Acids
24
Molecular Weight
≈2.6 kDa
Half-life
≈1-3 h
Research Score
4.0
Studies
78
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is p277?
A 24-amino-acid HSP60-derived peptide developed to promote immune tolerance and reduce inflammatory autoimmunity. It has been most visible in type 1 diabetes research, but it is a bona fide peptide immunomodulator in the autoimmune space.
Key Benefits & Mechanisms
immune tolerance
Treg bias
anti-inflammatory signaling
Research Summary
p277 is a real peptide with extensive autoimmune-trial history, especially in diabetes and tolerance research. It is not approved for autoimmune disease, but it remains a canonical example of a tolerogenic peptide platform.
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