hCDR1
Human complementarity-determining region 1 peptide (Edratide)
19 Amino Acids · MW: ≈2.1 kDa
Amino Acids
19
Molecular Weight
≈2.1 kDa
Half-life
≈1-2 h
Research Score
4.2
Studies
82
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is hCDR1?
A synthetic 19-mer derived from a human anti-DNA antibody sequence and developed as an immunomodulatory peptide for SLE. It has been studied for dampening pathogenic anti-dsDNA responses and restoring immune balance.
Key Benefits & Mechanisms
anti-dsDNA suppression
tolerogenic signaling
possible renal benefit
Research Summary
hCDR1, also called Edratide, is a real lupus peptide that reached clinical testing. It showed biologic activity in early studies, but it has not become an approved therapy.
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