dnaJP1
dnaJ heat-shock protein 70-derived peptide
21 Amino Acids · MW: ≈2.3 kDa
Amino Acids
21
Molecular Weight
≈2.3 kDa
Half-life
≈1-3 h
Research Score
4.1
Studies
80
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is dnaJP1?
A synthetic peptide derived from the bacterial dnaJ/heat-shock protein family that was evaluated as an antigen-specific therapy in rheumatoid arthritis. The concept is to induce regulatory immune responses to shared heat-shock protein epitopes.
Key Benefits & Mechanisms
RA immune modulation
regulatory T-cell induction
reduced inflammatory signaling
Research Summary
dnaJP1 is a real RA peptide that advanced into human studies as a tolerizing immunotherapy. Clinical development showed feasibility and immune effects, though it did not become a standard treatment.
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