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Diabetes & MetabolicPre-clinical

Irisin

Irisin (FNDC5 cleavage product)

112 Amino Acids · MW: ~12.3 kDa

Amino Acids

112

Molecular Weight

~12.3 kDa

Half-life

hours

Research Score

5.0

Studies

79

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Irisin?

Irisin is a cleavage product of FNDC5 that has been studied for exercise-linked improvements in glucose homeostasis and energy expenditure. It can influence AMPK, SIRT1, and PGC-1α signaling in metabolic tissues.

Key Benefits & Mechanisms

glucose homeostasis

energy expenditure

brown-fat activation

Research Summary

Irisin is widely explored in obesity and type 2 diabetes research because it connects exercise biology with metabolic adaptation. Human findings are mixed, so it remains a biomarker and preclinical lead rather than an approved therapy.