Glypromate
GPE
3 Amino Acids · MW: 301.3
Amino Acids
3
Molecular Weight
301.3
Half-life
short, minutes to hours
Research Score
4.0
Studies
88
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Glypromate?
A tripeptide composed of glycine-proline-glutamic acid and an endogenous IGF-1–related fragment. It has been studied in hypoxia-ischemia, stroke, and TBI models for neuronal survival and repair signaling.
Key Benefits & Mechanisms
neuronal survival
hypoxia-ischemia protection
repair signaling
Research Summary
Preclinical work suggests GPE can reduce injury from oxygen-glucose deprivation and support developmental and post-injury neuroprotection. It remains a research peptide without established standard clinical dosing for stroke or TBI.
Related Peptides
GPE
Glycyl-L-prolyl-L-glutamic acid
Glycyl-L-prolyl-L-glutamic acid (GPE) is a tripeptide derived from IGF-1 processing that has been studied for neuroprotection and synaptic support. It has been explored in models of learning, memory retention, and injury-related cognitive decline.
Cognitive EnhancementACTH (1-39)
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe
ACTH(1-39) is the full-length corticotropin peptide used clinically in MS relapse management via repository corticotropin products. Its relevance is primarily immunomodulatory and anti-inflammatory rather than disease-modifying.
NeurologicalFGL
Phe-Gly-Leu (NCAM-derived FGL peptide)
A short NCAM-mimetic peptide studied for neurite outgrowth, remyelination, and synaptic plasticity. It is especially relevant to MS-style demyelination and broader neurorepair concepts.
Neurological