ACTH (1-39)
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe
39 Amino Acids · MW: 4628.2 Da
Amino Acids
39
Molecular Weight
4628.2 Da
Half-life
0.25 h
Research Score
4.4
Studies
84
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is ACTH (1-39)?
ACTH(1-39) is the full-length corticotropin peptide used clinically in MS relapse management via repository corticotropin products. Its relevance is primarily immunomodulatory and anti-inflammatory rather than disease-modifying.
Key Benefits & Mechanisms
MS relapse control
anti-inflammatory signaling
melanocortin activity
Research Summary
Repository corticotropin remains an option for acute MS relapses, and ACTH biology is also studied for neuroinflammation and repair pathways in ALS and other CNS disorders.
Related Peptides
ACTH
Adrenocorticotropic Hormone (Corticotropin)
A 39-amino-acid melanocortin peptide derived from POMC with documented melanogenic activity. In skin biology, ACTH is a classic signal for melanocyte stimulation and hyperpigmentation research.
Skin & CosmeticGlypromate
GPE
A tripeptide composed of glycine-proline-glutamic acid and an endogenous IGF-1–related fragment. It has been studied in hypoxia-ischemia, stroke, and TBI models for neuronal survival and repair signaling.
NeurologicalFGL
Phe-Gly-Leu (NCAM-derived FGL peptide)
A short NCAM-mimetic peptide studied for neurite outgrowth, remyelination, and synaptic plasticity. It is especially relevant to MS-style demyelination and broader neurorepair concepts.
Neurological