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LongevityPre-clinical

FOXO4-DRI

FOXO4 D-Retro-Inverso Peptide

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Amino Acids

N/A

Molecular Weight

~4,500 Da

Half-life

Extended (D-amino acid resistant to proteases)

Research Score

4.0

Studies

28

Storage

N/A

What is FOXO4-DRI?

FOXO4-DRI is a cell-penetrating senolytic peptide that selectively targets and eliminates senescent (zombie) cells. It works by disrupting the interaction between FOXO4 and p53, causing senescent cells to undergo apoptosis while leaving healthy cells unaffected. A breakthrough in aging research.

Key Benefits & Mechanisms

Selective senescent cell elimination

Rejuvenation of aged tissues

Improved physical performance in aged models

Restoration of fur density and kidney function (animal studies)

Targeted senolytic action

Does not harm healthy cells

Potential anti-aging breakthrough

Research Summary

FOXO4-DRI made headlines from the 2017 Erasmus University study showing dramatic rejuvenation in aged mice. Senescent cells cleared from kidneys, liver, and skin. While animal data is remarkable, human clinical trials have not yet been conducted. One of the most exciting longevity research peptides.

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