Afamelanotide
[Nle4,D-Phe7]-alpha-melanocyte-stimulating hormone
13 Amino Acids · MW: 1631 Da
Amino Acids
13
Molecular Weight
1631 Da
Half-life
hours to days
Research Score
4.6
Studies
180
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Afamelanotide?
Afamelanotide is a synthetic alpha-MSH analog with greater stability and longer biological activity than the native peptide. While best known for pigmentation-related indications, it also has documented melanocortin-mediated anti-inflammatory effects.
Key Benefits & Mechanisms
reduces inflammatory cytokines
supports melanocortin receptor signaling
may protect tissues from inflammatory injury
has longer duration than native alpha-MSH
Research Summary
Afamelanotide is a stabilized melanocortin agonist derived from alpha-MSH and has been studied for tissue-protective and anti-inflammatory signaling. Its literature includes cytokine modulation and immunoregulatory effects, with the strongest real-world data coming from clinical use in erythropoietic protoporphyria.
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