Thymopentin vs HNP-1
Head-to-head comparison of Thymopentin (L-Arginyl-L-Lysyl-L-Aspartyl-L-Valyl-L-Tyrosine) and HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Thymopentin | HNP-1 |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | L-Arginyl-L-Lysyl-L-Aspartyl-L-Valyl-L-Tyrosine | Human Neutrophil Peptide 1 (Alpha-Defensin 1) |
| Molecular Weight | 676.78 Da | 3443 Da |
| Half-Life | 10-30 min | Minutes to hours; protease-sensitive |
| Amino Acids | 5 | 30 |
| Typical Dose | 1 mg | Research use only; no approved human dose |
| Route | Subcutaneous | Topical / Research parenteral |
| Purity | ≥98% | ≥98% |
| Studies Count | 90 | 610 |
| Research Status | Clinical | Pre-clinical |
Thymopentin Benefits
- ✓t-cell maturation
- ✓helper-suppressor balance
- ✓immune recovery
- ✓antiviral-adjunct research
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
Thymopentin Dosing
1 mg SC or IM|2-3x weekly|4-8 week study cycles
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Thymopentin Side Effects
- ⚠injection-site redness
- ⚠mild fever
- ⚠headache
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
Research Overview
Thymopentin
Thymopentin has a long history of preclinical and clinical investigation as a thymic peptide immunomodulator. Published studies report effects on T-cell subsets, cytokine responses, and immune recovery in recurrent infection settings.
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
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