Tesofensine vs Setmelanotide
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Setmelanotide (Setmelanotide Acetate) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Setmelanotide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Tesofensine (NS2330) | Setmelanotide Acetate |
| Molecular Weight | 426.52 g/mol | N/A |
| Half-Life | ~200-300 hours | Approximately 11-16 hours |
| Amino Acids | Small molecule | N/A |
| Typical Dose | — | 1-3 mg daily |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 80 |
| Research Status | Phase III Clinical Trials | Clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Setmelanotide Benefits
- ✓reduced hyperphagia
- ✓body-weight reduction
- ✓MC4R pathway activation
- ✓improved satiety signaling
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Setmelanotide Dosing
1 mg SC daily|titrate weekly to 2-3 mg/day|follow study or label-based escalation
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Setmelanotide Side Effects
- ⚠hyperpigmentation
- ⚠nausea
- ⚠injection-site reactions
- ⚠fatigue
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Setmelanotide
Setmelanotide has shown clinically meaningful reductions in hunger and weight in POMC, PCSK1, and LEPR-related obesity. It is one of the most important mechanistic peptides for rare-disease obesity research.
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