Tesofensine vs Secretin
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Secretin |
|---|---|---|
| Category | Weight Management | Gastrointestinal |
| Full Name | Tesofensine (NS2330) | Human Secretin |
| Molecular Weight | 426.52 g/mol | 3055.4 Da |
| Half-Life | ~200-300 hours | 5-7 minutes |
| Amino Acids | Small molecule | 27 |
| Typical Dose | — | 0.2 mcg/kg IV |
| Route | — | Intravenous |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 800 |
| Research Status | Phase III Clinical Trials | Clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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