Tesofensine vs Neuropeptide S
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Neuropeptide S (Neuropeptide S) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Neuropeptide S |
|---|---|---|
| Category | Weight Management | Cognitive Enhancement |
| Full Name | Tesofensine (NS2330) | Neuropeptide S |
| Molecular Weight | 426.52 g/mol | 2203 Da |
| Half-Life | ~200-300 hours | Minutes to <1 hour |
| Amino Acids | Small molecule | 20 |
| Typical Dose | — | Research-only; no validated human dose |
| Route | — | Intracerebroventricular/Intranasal |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 28 |
| Research Status | Phase III Clinical Trials | Pre-clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
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