Tesofensine vs Elamipretide
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Elamipretide (Elamipretide (MTP-131, SS-31)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Elamipretide |
|---|---|---|
| Category | Weight Management | Muscle & Performance |
| Full Name | Tesofensine (NS2330) | Elamipretide (MTP-131, SS-31) |
| Molecular Weight | 426.52 g/mol | 639.8 Da |
| Half-Life | ~200-300 hours | 1-4 hours |
| Amino Acids | Small molecule | 4 |
| Typical Dose | — | 0.01-0.25 mg/kg/day |
| Route | — | Subcutaneous/Intravenous |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 120 |
| Research Status | Phase III Clinical Trials | Clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
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