Secretin vs REGN1033
Head-to-head comparison of Secretin (Human Secretin) and REGN1033 (Trevogrumab (REGN1033)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | REGN1033 |
|---|---|---|
| Category | Gastrointestinal | Muscle & Performance |
| Full Name | Human Secretin | Trevogrumab (REGN1033) |
| Molecular Weight | 3055.4 Da | ~150 kDa |
| Half-Life | 5-7 minutes | ~2-3 weeks |
| Amino Acids | 27 | N/A |
| Typical Dose | 0.2 mcg/kg IV | 100-300 mg SC or equivalent trial dosing |
| Route | Intravenous | Subcutaneous / Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 60 |
| Research Status | Clinical | Clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
REGN1033 Benefits
- ✓myostatin blockade
- ✓lean-mass preservation
- ✓muscle hypertrophy support
- ✓catabolic-state countermeasure
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
REGN1033 Dosing
SC or IV clinical-trial dosing|repeat every 2-4 weeks|dose escalation by study
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
REGN1033 Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠fatigue
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
REGN1033
Human and animal studies indicate that myostatin neutralization can increase muscle size, though functional gains are often smaller than mass gains. Trevogrumab is part of the broader literature showing that selective myostatin inhibition can alter body composition in clinically meaningful ways.
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