Secretin vs ACE-031
Head-to-head comparison of Secretin (Human Secretin) and ACE-031 (ACE-031 (soluble activin receptor type IIB-Fc)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | ACE-031 |
|---|---|---|
| Category | Gastrointestinal | Muscle & Performance |
| Full Name | Human Secretin | ACE-031 (soluble activin receptor type IIB-Fc) |
| Molecular Weight | 3055.4 Da | ~95 kDa |
| Half-Life | 5-7 minutes | Days to weeks |
| Amino Acids | 27 | N/A |
| Typical Dose | 0.2 mcg/kg IV | 0.1-3 mg/kg in early studies |
| Route | Intravenous | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 75 |
| Research Status | Clinical | Clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
ACE-031 Benefits
- ✓myostatin/activin neutralization
- ✓lean mass gain
- ✓muscle function support
- ✓anti-catabolic effect
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
ACE-031 Dosing
Clinical studies used single or repeated SC doses|dose escalation in mg/kg|monitoring for edema/bleeding
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
ACE-031 Side Effects
- ⚠telangiectasia/vascular effects
- ⚠epistaxis
- ⚠headache/edema
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
ACE-031
ACE-031 produced increases in lean mass in early studies, but development was curtailed after safety concerns and variable efficacy. Its literature remains important because it validated activin receptor blockade as a muscle-building strategy.
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