Calcitonin vs Met-enkephalin
Head-to-head comparison of Calcitonin (Salmon Calcitonin) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Calcitonin | Met-enkephalin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Salmon Calcitonin | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 3431.9 Da | 573.67 Da |
| Half-Life | about 10-15 minutes | 1-5 minutes in plasma |
| Amino Acids | 32 | 5 |
| Typical Dose | 100 IU/day SC or 200 IU/day intranasal | 0.1-5 ug per animal |
| Route | Intranasal/Subcutaneous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 350 | 1200 |
| Research Status | Approved | Pre-clinical |
Calcitonin Benefits
- ✓bone pain relief
- ✓short-term analgesic effect
- ✓may reduce opioid requirement
- ✓useful in osteoporotic fracture pain
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Calcitonin Dosing
100 IU subcutaneous daily|200 IU intranasal daily|short-term use in acute pain settings
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Calcitonin Side Effects
- ⚠nausea
- ⚠flushing
- ⚠rhinitis
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
Calcitonin
Calcitonin has been evaluated in randomized trials and reviews for pain associated with vertebral compression fractures and other bone-related conditions. The signal is strongest for short-term analgesia rather than long-term chronic pain control.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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