Calcitonin vs Leu-enkephalin
Head-to-head comparison of Calcitonin (Salmon Calcitonin) and Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Calcitonin | Leu-enkephalin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Salmon Calcitonin | Tyr-Gly-Gly-Phe-Leu |
| Molecular Weight | 3431.9 Da | 555.63 Da |
| Half-Life | about 10-15 minutes | 1-5 minutes in plasma |
| Amino Acids | 32 | 5 |
| Typical Dose | 100 IU/day SC or 200 IU/day intranasal | 0.1-5 ug per animal |
| Route | Intranasal/Subcutaneous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 350 | 1000 |
| Research Status | Approved | Pre-clinical |
Calcitonin Benefits
- ✓bone pain relief
- ✓short-term analgesic effect
- ✓may reduce opioid requirement
- ✓useful in osteoporotic fracture pain
Leu-enkephalin Benefits
- ✓delta-opioid activity
- ✓endogenous analgesic model
- ✓receptor-selective pharmacology
- ✓nociception pathway research
Calcitonin Dosing
100 IU subcutaneous daily|200 IU intranasal daily|short-term use in acute pain settings
Leu-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Calcitonin Side Effects
- ⚠nausea
- ⚠flushing
- ⚠rhinitis
Leu-enkephalin Side Effects
- ⚠sedation
- ⚠constipation-like opioid effects
- ⚠very short plasma stability
Research Overview
Calcitonin
Calcitonin has been evaluated in randomized trials and reviews for pain associated with vertebral compression fractures and other bone-related conditions. The signal is strongest for short-term analgesia rather than long-term chronic pain control.
Leu-enkephalin
Leu-enkephalin is a standard tool in opioid receptor and pain-transmission research because it helps distinguish delta- from mu-preferring signaling. Its research value is high, but its clinical utility is limited by rapid enzymatic breakdown and delivery challenges.
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