Leu-enkephalin vs Neurotensin
Head-to-head comparison of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Neurotensin (Neurotensin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Leu-enkephalin | Neurotensin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Gly-Gly-Phe-Leu | Neurotensin |
| Molecular Weight | 555.63 Da | 1672.94 |
| Half-Life | 1-5 minutes in plasma | minutes |
| Amino Acids | 5 | 13 |
| Typical Dose | 0.1-5 ug per animal | N/A|N/A |
| Route | Intrathecal / intracerebroventricular | Intranasal/experimental injection |
| Purity | ≥98% | ≥98% |
| Studies Count | 1000 | 81 |
| Research Status | Pre-clinical | Pre-clinical |
Leu-enkephalin Benefits
- ✓delta-opioid activity
- ✓endogenous analgesic model
- ✓receptor-selective pharmacology
- ✓nociception pathway research
Neurotensin Benefits
- ✓antinociceptive signaling
- ✓descending pain modulation
- ✓preclinical pain research
Leu-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Neurotensin Dosing
N/A|N/A
Leu-enkephalin Side Effects
- ⚠sedation
- ⚠constipation-like opioid effects
- ⚠very short plasma stability
Neurotensin Side Effects
- ⚠hypotension
- ⚠nausea
- ⚠hypothermia
Research Overview
Leu-enkephalin
Leu-enkephalin is a standard tool in opioid receptor and pain-transmission research because it helps distinguish delta- from mu-preferring signaling. Its research value is high, but its clinical utility is limited by rapid enzymatic breakdown and delivery challenges.
Neurotensin
Neurotensin has reproducible analgesic and neuromodulatory effects in preclinical studies, especially in inflammatory and neuropathic pain paradigms. It is not a standard clinical analgesic, but it is a real non-opioid peptide with pain-relevant biology.
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