Orexin-A vs Hexarelin
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and Hexarelin (Growth Hormone Releasing Hexapeptide) — benefits, dosing, side effects, research data, and where to buy.
| Property | Orexin-A | Hexarelin |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Hypocretin-1 (Orexin-A) | Growth Hormone Releasing Hexapeptide |
| Molecular Weight | 3562 Da | 887.04 Da |
| Half-Life | Minutes to <1 hour | ~70 minutes |
| Amino Acids | 33 | 6 |
| Typical Dose | Research-only; no validated human dose | 100-200 mcg |
| Route | Intracerebroventricular/Intranasal | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 42 | 198 |
| Research Status | Pre-clinical | Clinical Trials |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
Hexarelin Benefits
- ✓Strongest GH pulse among GHRPs
- ✓Cardioprotective effects
- ✓Muscle mass and strength gains
- ✓Fat loss through improved body composition
- ✓Enhanced recovery from training
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
Hexarelin Dosing
Standard: 100-200 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100 mcg for overnight GH pulse|Cycle: 8-12 weeks then 4 week break (desensitization)
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
Hexarelin Side Effects
- ⚠Common: Increased appetite, water retention, tingling
- ⚠Moderate: Cortisol and prolactin elevation (dose-dependent)
- ⚠Notable: Desensitization occurs after 4-16 weeks of continuous use
- ⚠Rare: Numbness in extremities
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
Hexarelin
Hexarelin has extensive pre-clinical and clinical evidence. Multiple human studies confirm potent GH release. Unique cardioprotective properties are well-documented. Note that receptor desensitization limits long-term continuous use.
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