Orexin-A vs CJC-1295
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and CJC-1295 (Growth Hormone Releasing Hormone Analog) — benefits, dosing, side effects, research data, and where to buy.
| Property | Orexin-A | CJC-1295 |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Hypocretin-1 (Orexin-A) | Growth Hormone Releasing Hormone Analog |
| Molecular Weight | 3562 Da | 3,367.97 Da |
| Half-Life | Minutes to <1 hour | ~6-8 days (DAC) |
| Amino Acids | 33 | 30 |
| Typical Dose | Research-only; no validated human dose | 1-2 mg/week |
| Route | Intracerebroventricular/Intranasal | SC |
| Purity | ≥98% | — |
| Studies Count | 42 | 167 |
| Research Status | Pre-clinical | Clinical Trials |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
CJC-1295 Benefits
- ✓Sustained GH release over days
- ✓Improved body composition
- ✓Enhanced deep sleep quality
- ✓Accelerated recovery from training
- ✓Increased protein synthesis
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
CJC-1295 Dosing
Without DAC: 100-200 mcg SC 2-3 times daily|With DAC: 1-2 mg SC once or twice weekly|Combined with Ipamorelin: 100 mcg each, 2-3x daily
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
CJC-1295 Side Effects
- ⚠Common (Mild): Water retention, tingling/numbness, flushing
- ⚠Moderate: Joint stiffness, carpal tunnel-like symptoms
- ⚠Rare: Elevated blood sugar (transient)
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
CJC-1295
CJC-1295 has good pre-clinical and early clinical data. The DAC variant shows sustained GH elevation for days. Often combined with GHRPs for synergistic GH release.
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