Orexin-A vs IGF-1 LR3
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) — benefits, dosing, side effects, research data, and where to buy.
| Property | Orexin-A | IGF-1 LR3 |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Hypocretin-1 (Orexin-A) | Insulin-like Growth Factor-1 Long R3 |
| Molecular Weight | 3562 Da | 9,117 Da |
| Half-Life | Minutes to <1 hour | ~20-30 hours |
| Amino Acids | 33 | 83 |
| Typical Dose | Research-only; no validated human dose | 20-100 mcg |
| Route | Intracerebroventricular/Intranasal | IM / SC |
| Purity | ≥98% | — |
| Studies Count | 42 | 298 |
| Research Status | Pre-clinical | Pre-clinical |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
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