Orexin-A vs GHRP-6
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and GHRP-6 (Growth Hormone Releasing Peptide-6) — benefits, dosing, side effects, research data, and where to buy.
| Property | Orexin-A | GHRP-6 |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Hypocretin-1 (Orexin-A) | Growth Hormone Releasing Peptide-6 |
| Molecular Weight | 3562 Da | 873.01 Da |
| Half-Life | Minutes to <1 hour | ~15-60 minutes |
| Amino Acids | 33 | 6 |
| Typical Dose | Research-only; no validated human dose | 100-300 mcg |
| Route | Intracerebroventricular/Intranasal | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 42 | 186 |
| Research Status | Pre-clinical | Clinical Trials |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
GHRP-6 Benefits
- ✓Potent GH release stimulation
- ✓Muscle growth and strength
- ✓Appetite stimulation (ghrelin pathway)
- ✓Improved body composition
- ✓Enhanced recovery from training
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
GHRP-6 Dosing
Standard: 100-300 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100-200 mcg for overnight GH pulse
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
GHRP-6 Side Effects
- ⚠Common: Increased appetite (significant), water retention, tingling
- ⚠Moderate: Cortisol elevation (dose-dependent), lethargy
- ⚠Rare: Elevated prolactin at high doses
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
GHRP-6
GHRP-6 has solid pre-clinical and clinical evidence for GH stimulation. Well-characterized pharmacology. More appetite stimulation than Ipamorelin due to ghrelin receptor activation.
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