Orexin-A vs DSIP
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and DSIP (Delta Sleep-Inducing Peptide) — benefits, dosing, side effects, research data, and where to buy.
| Property | Orexin-A | DSIP |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Hypocretin-1 (Orexin-A) | Delta Sleep-Inducing Peptide |
| Molecular Weight | 3562 Da | 848.8 Da |
| Half-Life | Minutes to <1 hour | ~15-25 minutes |
| Amino Acids | 33 | 9 |
| Typical Dose | Research-only; no validated human dose | 100-200 mcg |
| Route | Intracerebroventricular/Intranasal | SC / IV / Intranasal |
| Purity | ≥98% | — |
| Studies Count | 42 | 74 |
| Research Status | Pre-clinical | Pre-clinical |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
DSIP Benefits
- ✓Promotes deep delta wave sleep
- ✓Normalizes disrupted sleep patterns
- ✓Reduces cortisol and stress response
- ✓Pain modulating effects
- ✓Antioxidant properties
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
DSIP Dosing
Standard: 100-200 mcg SC or IV, 30-60 min before bed|Cycle: 10-14 days, 5-7 days off|Chronic insomnia: 100 mcg daily for 2-3 weeks|Can be combined with Ipamorelin pre-bed
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
DSIP Side Effects
- ⚠Common (Mild): Morning grogginess initially, mild headache
- ⚠Rare: Vivid dreams, temporary appetite changes
- ⚠Generally very well tolerated
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
DSIP
DSIP has moderate clinical evidence from European studies. Human trials show improved sleep quality and normalized sleep-wake cycles. Also studied for alcohol and opiate withdrawal. Unique mechanism distinct from traditional sleep aids.
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