NPY vs IGF-2
Head-to-head comparison of NPY (Neuropeptide Y) and IGF-2 (Insulin-Like Growth Factor II) — benefits, dosing, side effects, research data, and where to buy.
| Property | NPY | IGF-2 |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Neuropeptide Y | Insulin-Like Growth Factor II |
| Molecular Weight | 4272 Da | 7467 Da |
| Half-Life | minutes | 6-10 minutes |
| Amino Acids | 36 aa | 67 aa |
| Typical Dose | 1-10 µg preclinical range | 1-10 µg preclinical range |
| Route | Intranasal | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 900 | 1200 |
| Research Status | Pre-clinical | Pre-clinical |
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
IGF-2 Benefits
- ✓memory consolidation
- ✓hippocampal plasticity
- ✓synaptic repair
- ✓neuroprotection
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
IGF-2 Dosing
0.1-1 µg ICV in rodents|1-10 µg intrahippocampal in preclinical work|acute post-training protocols
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
IGF-2 Side Effects
- ⚠hypoglycemia risk
- ⚠edema
- ⚠insulin-like systemic effects
Research Overview
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
IGF-2
IGF-2 has strong preclinical evidence for improving memory formation and supporting synaptic changes tied to learning. It also shows neuroprotective and repair-related effects in models of injury and neurodegeneration.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.