IGF-2

Insulin-Like Growth Factor II

67 aa Amino Acids · MW: 7467 Da

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Amino Acids

67 aa

Molecular Weight

7467 Da

Half-life

6-10 minutes

Research Score

4.6

Studies

1200

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is IGF-2?

IGF-2 is a growth factor studied for memory consolidation, synaptic remodeling, and recovery after brain injury. It is frequently discussed in the context of hippocampal plasticity and cognitive resilience.

Key Benefits & Mechanisms

memory consolidation

hippocampal plasticity

synaptic repair

neuroprotection

Research Summary

IGF-2 has strong preclinical evidence for improving memory formation and supporting synaptic changes tied to learning. It also shows neuroprotective and repair-related effects in models of injury and neurodegeneration.

Related Peptides

GPE

Glycyl-L-prolyl-L-glutamic acid

Glycyl-L-prolyl-L-glutamic acid (GPE) is a tripeptide derived from IGF-1 processing that has been studied for neuroprotection and synaptic support. It has been explored in models of learning, memory retention, and injury-related cognitive decline.

Cognitive Enhancement

Davunetide

Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)

Davunetide is an eight-amino-acid peptide, also known as NAP, derived from the ADNP protein. It has been studied for microtubule stabilization, neuroprotection, and potential effects on cognition in neurodegenerative and injury models.

Cognitive Enhancement

Noopept

N-phenylacetyl-L-prolylglycine ethyl ester

Noopept is a peptide-derived cognitive enhancer used as a research compound and sold in some markets as a nootropic. It is studied for memory, attention, and neurotrophic signaling, especially in animal and limited human data.

Cognitive Enhancement

Arginine Vasopressin

8-Arginine Vasopressin

Arginine vasopressin is a naturally occurring nonapeptide hormone that also has documented CNS effects on memory and social cognition. In research settings it has been studied for its potential to influence consolidation, recall, and arousal-linked learning.

Cognitive Enhancement