NPY vs GPE
Head-to-head comparison of NPY (Neuropeptide Y) and GPE (Glycyl-L-prolyl-L-glutamic acid) — benefits, dosing, side effects, research data, and where to buy.
| Property | NPY | GPE |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Neuropeptide Y | Glycyl-L-prolyl-L-glutamic acid |
| Molecular Weight | 4272 Da | 301.30 Da |
| Half-Life | minutes | minutes |
| Amino Acids | 36 aa | 3 |
| Typical Dose | 1-10 µg preclinical range | 0.1-10 mg/kg preclinical |
| Route | Intranasal | Intranasal/Intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 900 | 25 |
| Research Status | Pre-clinical | Pre-clinical |
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
GPE Benefits
- ✓memory consolidation
- ✓neuroprotection
- ✓synaptic plasticity
- ✓learning support
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
GPE Dosing
intranasal or ICV research doses|0.1-10 mg/kg preclinical range|repeat daily or intermittent protocols
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
GPE Side Effects
- ⚠limited human safety data
- ⚠short half-life
- ⚠local irritation with nasal delivery
Research Overview
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
GPE
Preclinical studies suggest GPE can reduce neuronal damage and support plasticity-related pathways in the brain. Research interest centers on hippocampal function, which links it to learning and memory paradigms.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.