NPY vs Noopept
Head-to-head comparison of NPY (Neuropeptide Y) and Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) — benefits, dosing, side effects, research data, and where to buy.
| Property | NPY | Noopept |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Neuropeptide Y | N-phenylacetyl-L-prolylglycine ethyl ester |
| Molecular Weight | 4272 Da | 318.37 Da |
| Half-Life | minutes | 20-30 minutes |
| Amino Acids | 36 aa | N/A |
| Typical Dose | 1-10 µg preclinical range | 10-30 mg/day |
| Route | Intranasal | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 900 | 60 |
| Research Status | Pre-clinical | Clinical |
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Noopept Benefits
- ✓memory recall
- ✓learning efficiency
- ✓attention support
- ✓neurotrophic signaling
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Noopept Dosing
oral research use|10-30 mg per day in human studies|divided or single daily dosing
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Noopept Side Effects
- ⚠headache
- ⚠irritability
- ⚠sleep disturbance
Research Overview
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
Noopept
Noopept has been reported to increase NGF/BDNF-related signaling and improve performance in tasks involving learning and recall. Evidence includes preclinical studies and small human studies, but the overall literature is still modest compared with mainstream cognitive drugs.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.