Noopept vs IGF-2
Head-to-head comparison of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) and IGF-2 (Insulin-Like Growth Factor II) — benefits, dosing, side effects, research data, and where to buy.
| Property | Noopept | IGF-2 |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | N-phenylacetyl-L-prolylglycine ethyl ester | Insulin-Like Growth Factor II |
| Molecular Weight | 318.37 Da | 7467 Da |
| Half-Life | 20-30 minutes | 6-10 minutes |
| Amino Acids | N/A | 67 aa |
| Typical Dose | 10-30 mg/day | 1-10 µg preclinical range |
| Route | Oral | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 60 | 1200 |
| Research Status | Clinical | Pre-clinical |
Noopept Benefits
- ✓memory recall
- ✓learning efficiency
- ✓attention support
- ✓neurotrophic signaling
IGF-2 Benefits
- ✓memory consolidation
- ✓hippocampal plasticity
- ✓synaptic repair
- ✓neuroprotection
Noopept Dosing
oral research use|10-30 mg per day in human studies|divided or single daily dosing
IGF-2 Dosing
0.1-1 µg ICV in rodents|1-10 µg intrahippocampal in preclinical work|acute post-training protocols
Noopept Side Effects
- ⚠headache
- ⚠irritability
- ⚠sleep disturbance
IGF-2 Side Effects
- ⚠hypoglycemia risk
- ⚠edema
- ⚠insulin-like systemic effects
Research Overview
Noopept
Noopept has been reported to increase NGF/BDNF-related signaling and improve performance in tasks involving learning and recall. Evidence includes preclinical studies and small human studies, but the overall literature is still modest compared with mainstream cognitive drugs.
IGF-2
IGF-2 has strong preclinical evidence for improving memory formation and supporting synaptic changes tied to learning. It also shows neuroprotective and repair-related effects in models of injury and neurodegeneration.
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