IGF-2 vs NPY
Head-to-head comparison of IGF-2 (Insulin-Like Growth Factor II) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
| Property | IGF-2 | NPY |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Insulin-Like Growth Factor II | Neuropeptide Y |
| Molecular Weight | 7467 Da | 4272 Da |
| Half-Life | 6-10 minutes | minutes |
| Amino Acids | 67 aa | 36 aa |
| Typical Dose | 1-10 µg preclinical range | 1-10 µg preclinical range |
| Route | Intranasal | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 900 |
| Research Status | Pre-clinical | Pre-clinical |
IGF-2 Benefits
- ✓memory consolidation
- ✓hippocampal plasticity
- ✓synaptic repair
- ✓neuroprotection
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
IGF-2 Dosing
0.1-1 µg ICV in rodents|1-10 µg intrahippocampal in preclinical work|acute post-training protocols
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
IGF-2 Side Effects
- ⚠hypoglycemia risk
- ⚠edema
- ⚠insulin-like systemic effects
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
IGF-2
IGF-2 has strong preclinical evidence for improving memory formation and supporting synaptic changes tied to learning. It also shows neuroprotective and repair-related effects in models of injury and neurodegeneration.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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