IGF-2 vs Davunetide
Head-to-head comparison of IGF-2 (Insulin-Like Growth Factor II) and Davunetide (Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | IGF-2 | Davunetide |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Insulin-Like Growth Factor II | Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ) |
| Molecular Weight | 7467 Da | 796.9 Da |
| Half-Life | 6-10 minutes | short; minutes to low hours |
| Amino Acids | 67 aa | 8 |
| Typical Dose | 1-10 µg preclinical range | 1-10 mg/day research range |
| Route | Intranasal | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 40 |
| Research Status | Pre-clinical | Clinical/Pre-clinical |
IGF-2 Benefits
- ✓memory consolidation
- ✓hippocampal plasticity
- ✓synaptic repair
- ✓neuroprotection
Davunetide Benefits
- ✓neuroprotection
- ✓microtubule support
- ✓attention support
- ✓memory preservation
IGF-2 Dosing
0.1-1 µg ICV in rodents|1-10 µg intrahippocampal in preclinical work|acute post-training protocols
Davunetide Dosing
intranasal research dosing|1-10 mg per dose in trials/preclinical work|once or twice daily
IGF-2 Side Effects
- ⚠hypoglycemia risk
- ⚠edema
- ⚠insulin-like systemic effects
Davunetide Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠limited efficacy in late-stage trials
Research Overview
IGF-2
IGF-2 has strong preclinical evidence for improving memory formation and supporting synaptic changes tied to learning. It also shows neuroprotective and repair-related effects in models of injury and neurodegeneration.
Davunetide
Preclinical work showed davunetide can protect neurons, preserve synaptic structure, and improve performance in memory tasks. Human trials largely focused on neurodegenerative disease outcomes rather than stand-alone nootropic use, but the literature supports CNS activity.
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