IGF-2 vs NGF
Head-to-head comparison of IGF-2 (Insulin-Like Growth Factor II) and NGF (Beta-Nerve Growth Factor (human NGF beta)) — benefits, dosing, side effects, research data, and where to buy.
| Property | IGF-2 | NGF |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Insulin-Like Growth Factor II | Beta-Nerve Growth Factor (human NGF beta) |
| Molecular Weight | 7467 Da | 13,600 Da |
| Half-Life | 6-10 minutes | hours |
| Amino Acids | 67 aa | 118 aa |
| Typical Dose | 1-10 µg preclinical range | research-only microgram range |
| Route | Intranasal | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 3500 |
| Research Status | Pre-clinical | Pre-clinical |
IGF-2 Benefits
- ✓memory consolidation
- ✓hippocampal plasticity
- ✓synaptic repair
- ✓neuroprotection
NGF Benefits
- ✓neurite outgrowth
- ✓cholinergic support
- ✓nerve repair
- ✓neuroprotection
IGF-2 Dosing
0.1-1 µg ICV in rodents|1-10 µg intrahippocampal in preclinical work|acute post-training protocols
NGF Dosing
0.01-1 µg/kg in experimental delivery studies|local CNS or intranasal research delivery|single or repeated low-dose protocols
IGF-2 Side Effects
- ⚠hypoglycemia risk
- ⚠edema
- ⚠insulin-like systemic effects
NGF Side Effects
- ⚠pain at injection site
- ⚠hyperalgesia
- ⚠autonomic effects
Research Overview
IGF-2
IGF-2 has strong preclinical evidence for improving memory formation and supporting synaptic changes tied to learning. It also shows neuroprotective and repair-related effects in models of injury and neurodegeneration.
NGF
NGF is one of the most established growth factors in neurobiology and has been investigated for both central and peripheral neuronal repair. Its strongest cognitive relevance comes from supporting basal forebrain cholinergic neurons and downstream memory circuitry.
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