NGF vs NPY
Head-to-head comparison of NGF (Beta-Nerve Growth Factor (human NGF beta)) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
| Property | NGF | NPY |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Beta-Nerve Growth Factor (human NGF beta) | Neuropeptide Y |
| Molecular Weight | 13,600 Da | 4272 Da |
| Half-Life | hours | minutes |
| Amino Acids | 118 aa | 36 aa |
| Typical Dose | research-only microgram range | 1-10 µg preclinical range |
| Route | Intranasal | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 3500 | 900 |
| Research Status | Pre-clinical | Pre-clinical |
NGF Benefits
- ✓neurite outgrowth
- ✓cholinergic support
- ✓nerve repair
- ✓neuroprotection
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
NGF Dosing
0.01-1 µg/kg in experimental delivery studies|local CNS or intranasal research delivery|single or repeated low-dose protocols
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
NGF Side Effects
- ⚠pain at injection site
- ⚠hyperalgesia
- ⚠autonomic effects
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
NGF
NGF is one of the most established growth factors in neurobiology and has been investigated for both central and peripheral neuronal repair. Its strongest cognitive relevance comes from supporting basal forebrain cholinergic neurons and downstream memory circuitry.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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