Neuropeptide S vs Tianeptine sodium
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and Tianeptine sodium (Tianeptine sodium) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | Tianeptine sodium |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Neuropeptide S | Tianeptine sodium |
| Molecular Weight | 2203 Da | 458.94 Da |
| Half-Life | Minutes to <1 hour | About 2.5 hours |
| Amino Acids | 20 | N/A |
| Typical Dose | Research-only; no validated human dose | 12.5 mg 3 times daily |
| Route | Intracerebroventricular/Intranasal | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 28 | 280 |
| Research Status | Pre-clinical | Clinical |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
Tianeptine sodium Benefits
- ✓mood improvement
- ✓anxiety reduction
- ✓cognitive clarity
- ✓stress adaptation
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
Tianeptine sodium Dosing
12.5 mg oral 3x/day|25 mg/day oral|clinical antidepressant dosing
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Tianeptine sodium Side Effects
- ⚠nausea
- ⚠dizziness
- ⚠dependence risk
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
Tianeptine sodium
Clinical studies support tianeptine as an antidepressant with a distinctive glutamatergic and neuroplasticity-related profile. Some evidence suggests cognitive benefits in mood-impaired populations, likely secondary to improved stress handling and affect.
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