Neuropeptide S vs Davunetide
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and Davunetide (Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | Davunetide |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Neuropeptide S | Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ) |
| Molecular Weight | 2203 Da | 796.9 Da |
| Half-Life | Minutes to <1 hour | short; minutes to low hours |
| Amino Acids | 20 | 8 |
| Typical Dose | Research-only; no validated human dose | 1-10 mg/day research range |
| Route | Intracerebroventricular/Intranasal | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 28 | 40 |
| Research Status | Pre-clinical | Clinical/Pre-clinical |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
Davunetide Benefits
- ✓neuroprotection
- ✓microtubule support
- ✓attention support
- ✓memory preservation
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
Davunetide Dosing
intranasal research dosing|1-10 mg per dose in trials/preclinical work|once or twice daily
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Davunetide Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠limited efficacy in late-stage trials
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
Davunetide
Preclinical work showed davunetide can protect neurons, preserve synaptic structure, and improve performance in memory tasks. Human trials largely focused on neurodegenerative disease outcomes rather than stand-alone nootropic use, but the literature supports CNS activity.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.