Tianeptine sodium vs PACAP-38
Head-to-head comparison of Tianeptine sodium (Tianeptine sodium) and PACAP-38 (Pituitary Adenylate Cyclase-Activating Polypeptide-38 (human PACAP-38)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tianeptine sodium | PACAP-38 |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Tianeptine sodium | Pituitary Adenylate Cyclase-Activating Polypeptide-38 (human PACAP-38) |
| Molecular Weight | 458.94 Da | 4534 Da |
| Half-Life | About 2.5 hours | minutes |
| Amino Acids | N/A | 38 aa |
| Typical Dose | 12.5 mg 3 times daily | 10-100 µg preclinical range |
| Route | Oral | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 280 | 650 |
| Research Status | Clinical | Pre-clinical |
Tianeptine sodium Benefits
- ✓mood improvement
- ✓anxiety reduction
- ✓cognitive clarity
- ✓stress adaptation
PACAP-38 Benefits
- ✓synaptic plasticity
- ✓BDNF upregulation
- ✓neuroprotection
- ✓memory consolidation
Tianeptine sodium Dosing
12.5 mg oral 3x/day|25 mg/day oral|clinical antidepressant dosing
PACAP-38 Dosing
0.1-1 nmol ICV in rodents|10-100 µg intranasal in preclinical studies|single-dose or short repeated protocols
Tianeptine sodium Side Effects
- ⚠nausea
- ⚠dizziness
- ⚠dependence risk
PACAP-38 Side Effects
- ⚠headache-like effects
- ⚠flushing
- ⚠hypotension
Research Overview
Tianeptine sodium
Clinical studies support tianeptine as an antidepressant with a distinctive glutamatergic and neuroplasticity-related profile. Some evidence suggests cognitive benefits in mood-impaired populations, likely secondary to improved stress handling and affect.
PACAP-38
PACAP-38 is one of the most studied endogenous neuropeptides for protecting neurons from ischemic and excitotoxic damage. Preclinical literature also links it to hippocampal plasticity and learning-related signaling, including increased BDNF expression.
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