PACAP-38
Pituitary Adenylate Cyclase-Activating Polypeptide-38 (human PACAP-38)
38 aa Amino Acids · MW: 4534 Da
Amino Acids
38 aa
Molecular Weight
4534 Da
Half-life
minutes
Research Score
4.5
Studies
650
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is PACAP-38?
PACAP-38 is a 38-amino-acid neuropeptide with strong CNS trophic signaling and broad neuroprotective activity. It is studied for effects on memory, neuronal survival, and synaptic plasticity through cAMP and BDNF-related pathways.
Key Benefits & Mechanisms
synaptic plasticity
BDNF upregulation
neuroprotection
memory consolidation
Research Summary
PACAP-38 is one of the most studied endogenous neuropeptides for protecting neurons from ischemic and excitotoxic damage. Preclinical literature also links it to hippocampal plasticity and learning-related signaling, including increased BDNF expression.
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