Tianeptine sodium vs Davunetide
Head-to-head comparison of Tianeptine sodium (Tianeptine sodium) and Davunetide (Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tianeptine sodium | Davunetide |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Tianeptine sodium | Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ) |
| Molecular Weight | 458.94 Da | 796.9 Da |
| Half-Life | About 2.5 hours | short; minutes to low hours |
| Amino Acids | N/A | 8 |
| Typical Dose | 12.5 mg 3 times daily | 1-10 mg/day research range |
| Route | Oral | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 280 | 40 |
| Research Status | Clinical | Clinical/Pre-clinical |
Tianeptine sodium Benefits
- ✓mood improvement
- ✓anxiety reduction
- ✓cognitive clarity
- ✓stress adaptation
Davunetide Benefits
- ✓neuroprotection
- ✓microtubule support
- ✓attention support
- ✓memory preservation
Tianeptine sodium Dosing
12.5 mg oral 3x/day|25 mg/day oral|clinical antidepressant dosing
Davunetide Dosing
intranasal research dosing|1-10 mg per dose in trials/preclinical work|once or twice daily
Tianeptine sodium Side Effects
- ⚠nausea
- ⚠dizziness
- ⚠dependence risk
Davunetide Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠limited efficacy in late-stage trials
Research Overview
Tianeptine sodium
Clinical studies support tianeptine as an antidepressant with a distinctive glutamatergic and neuroplasticity-related profile. Some evidence suggests cognitive benefits in mood-impaired populations, likely secondary to improved stress handling and affect.
Davunetide
Preclinical work showed davunetide can protect neurons, preserve synaptic structure, and improve performance in memory tasks. Human trials largely focused on neurodegenerative disease outcomes rather than stand-alone nootropic use, but the literature supports CNS activity.
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