Tianeptine sodium vs NPY
Head-to-head comparison of Tianeptine sodium (Tianeptine sodium) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tianeptine sodium | NPY |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Tianeptine sodium | Neuropeptide Y |
| Molecular Weight | 458.94 Da | 4272 Da |
| Half-Life | About 2.5 hours | minutes |
| Amino Acids | N/A | 36 aa |
| Typical Dose | 12.5 mg 3 times daily | 1-10 µg preclinical range |
| Route | Oral | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 280 | 900 |
| Research Status | Clinical | Pre-clinical |
Tianeptine sodium Benefits
- ✓mood improvement
- ✓anxiety reduction
- ✓cognitive clarity
- ✓stress adaptation
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Tianeptine sodium Dosing
12.5 mg oral 3x/day|25 mg/day oral|clinical antidepressant dosing
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Tianeptine sodium Side Effects
- ⚠nausea
- ⚠dizziness
- ⚠dependence risk
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
Tianeptine sodium
Clinical studies support tianeptine as an antidepressant with a distinctive glutamatergic and neuroplasticity-related profile. Some evidence suggests cognitive benefits in mood-impaired populations, likely secondary to improved stress handling and affect.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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