MK-677 vs Secretin
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
| Property | MK-677 | Secretin |
|---|---|---|
| Category | Growth Hormone | Gastrointestinal |
| Full Name | Ibutamoren Mesylate (MK-677) | Human Secretin |
| Molecular Weight | 528.662 g/mol | 3055.4 Da |
| Half-Life | ~24 hours | 5-7 minutes |
| Amino Acids | Non-peptide compound | 27 |
| Typical Dose | — | 0.2 mcg/kg IV |
| Route | — | Intravenous |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 800 |
| Research Status | Active Research | Clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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