MK-677 vs Plecanatide
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Plecanatide (Plecanatide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Plecanatide |
|---|---|---|
| Category | Growth Hormone | Gastrointestinal |
| Full Name | Ibutamoren Mesylate (MK-677) | Plecanatide |
| Molecular Weight | 528.662 g/mol | Approx. 1620 Da |
| Half-Life | ~24 hours | Local intestinal action; systemic half-life not clinically meaningful |
| Amino Acids | Non-peptide compound | 16 |
| Typical Dose | — | 3 mg once daily |
| Route | — | Oral |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 350 |
| Research Status | Active Research | Clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Plecanatide Benefits
- ✓improves-stool-frequency
- ✓supports-fluid-secretion
- ✓may-reduce-constipation
- ✓local-gut-action
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Plecanatide Dosing
3 mg PO daily|take with or without food|avoid when dehydrated
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Plecanatide Side Effects
- ⚠diarrhea
- ⚠abdominal-discomfort
- ⚠nausea
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Plecanatide
Clinical trials show plecanatide improves constipation outcomes with a generally favorable tolerability profile. Like linaclotide, it acts locally in the intestinal lumen via GC-C signaling rather than systemic hormone effects.
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