MK-677 vs IGF-1 DES
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and IGF-1 DES (Des(1-3) Insulin-like Growth Factor 1) — benefits, dosing, side effects, research data, and where to buy.
| Property | MK-677 | IGF-1 DES |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ibutamoren Mesylate (MK-677) | Des(1-3) Insulin-like Growth Factor 1 |
| Molecular Weight | 528.662 g/mol | 7365 Da |
| Half-Life | ~24 hours | ~20-30 minutes |
| Amino Acids | Non-peptide compound | 67 |
| Typical Dose | — | — |
| Route | — | — |
| Purity | >99% | >98% |
| Studies Count | 120 | 65 |
| Research Status | Active Research | Active Research |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
IGF-1 DES Benefits
- ✓Highly potent localized muscle growth, enhanced protein synthesis, satellite cell proliferation, does not bind to IGFBPs, rapid onset
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
IGF-1 DES Dosing
50-150 mcg per injection site bilaterally post-workout. 4-6 week cycles due to potency. Multiple daily injections in research.
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
IGF-1 DES Side Effects
- ⚠Hypoglycemia (dose-dependent), localized swelling, shorter duration limits systemic exposure compared to IGF-1 LR3.
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
IGF-1 DES
Missing first three amino acids (Gly-Pro-Glu) eliminates IGFBP binding, resulting in 100% bioavailable IGF-1R stimulation. Activates PI3K/Akt/mTOR for protein synthesis and satellite cell proliferation.
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