MK-677 vs Cosyntropin
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Cosyntropin (Cosyntropin (ACTH 1-24)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Cosyntropin |
|---|---|---|
| Category | Growth Hormone | Pain Management |
| Full Name | Ibutamoren Mesylate (MK-677) | Cosyntropin (ACTH 1-24) |
| Molecular Weight | 528.662 g/mol | 2933.3 Da |
| Half-Life | ~24 hours | ~10 min |
| Amino Acids | Non-peptide compound | 24 |
| Typical Dose | — | 0.25 mg IV/IM diagnostic dose|off-label headache protocols vary |
| Route | — | IV|IM |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 61 |
| Research Status | Active Research | Clinical research |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Cosyntropin Benefits
- ✓refractory migraine
- ✓anti-inflammatory signaling
- ✓headache rescue research
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Cosyntropin Dosing
0.25 mg IV/IM|1 mg IV/IM
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Cosyntropin Side Effects
- ⚠flushing
- ⚠nausea
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Cosyntropin
Cosyntropin is not a standard pain drug, but it appears in headache literature because ACTH analogs can help some patients with difficult migraine attacks. The analgesic rationale is partly tied to steroidogenic and anti-inflammatory effects.
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